Wartocell: Transplantation of allogeneic cell for the treatment of cerebral palsy

Cell therapy is the safest and most secure treatment

Allogeneic transplantation is the result of the isolation and culturing of healthy donor cells. In other words, the patient receives the cells from another person. For this product, after receiving the acceptable results, viral and biochemical tests are performed on the blood sample of the donor and processing and culturing will be done in a sterile condition. This product contains living cells that, after being isolated from healthy donor tissue, are propagated in a standard culture medium and stored in sterile vials in a nitrogen tank until the injection is requested.

Allogeneic cells, while expressing estrogenic characteristics, have the ability to proliferate and differentiate into mesodermal categories, including bone, cartilage, and fat. These cells are also able to control inflammation and modulate immune responses in the body, as well as the ability to differentiate into vascular cells and create new blood vessels. One of the advantages of this method is the high quality of the cells. In some patients, the cells do not have enough quality to reproduce, and in this case, it is better to use allogeneic cells.

In this method, there is no need to take the cell from patients because the cells are available in large quantities at an allogeneic bank. Also, since the cells have already been cultured and multiplied, the injection process can be done faster.  As a result, the transplantation increases the patient’s definitive recovery and life expectancy in different patients.

Allogeneic transplantation is the safest and most secure treatment.

Cerebral Palsy (CP) is the most common chronic physical disorder in children, and it includes a group of non-progressive disorders resulting from brain damage.  It develops in the brain of the fetus or infant, and is often associated with motor impairment, vision problems, hearing impairment, lack of coordination, and may impact cognitive, mental, and behavioural issues.

This disease is one of the significant problems in pediatric neurology and imposes many economic and social issues on individuals, the family and the health system.

Types of cerebral palsy based on the intensity and shape of its mould according to GMFCS (Gross Motor Function Classification System):


  1. Spastic (motor and spastic disorder) is the most common type of CP that results from damage to the upper motor neurons located in the pyramidal pathway (pyramidal).
  2. Athethoid
  3. Dystonic
  4. Hypotonic
  5. Ataxic is a rare type of CP that occurs in less than 5% of cases. In general, it is the most common type of spastic cerebral palsy. The main known risk factors for this disease are premature birth, intrauterine growth restriction (IUGR), intrauterine infection. In addition, the condition is more common in males.

At the moment, there have been numerous rehabilitation and medical interventions to help these patients increase their functional skills, regardless of their permanent physical disability. However, there is no effective drug, effective rehabilitation, or surgical treatment for these conditions.